TAXUS Woman Analysis

In a pooled analysis of 5 randomized controlled trials and 2 real-world registries, Mikhail et al assessed sex-based long-term outcomes in more than 3000 women following paclitaxel-eluting stent (PES) implantation. The authors found that women had more adverse baseline clinical characteristics including advanced age, hypertension and diabetes than men. Despite this, women had similar outcomes to men following PES implantation when compared to BMS implantation. However, higher death rates and target lesion revascularization rates were found in a high-risk subset of women. The TAXUS woman analysis represents the largest evaluation to-date of women undergoing percutaneous coronary intervention and shows that despite a higher baseline risk profile, PES outcomes are comparable between the sexes.

Reference:
Mikhail et al. Influence of sex on long-term outcomes after percutaneous coronary intervention with the paclitaxel-eluting coronary stent. JACC Cardiovascular Interventions 3 (12) 1250-9

Rasha Al-Lamee
Co-editor WIN blog

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